gloriosa superba poisoning treatment

Toxic encephalopathy due to colchicine— Gloriosa superba poisoning Inuka Kishara Gooneratne 1, Praveen Weeratunga 2, Manjula Caldera 1, Ranjanie Gamage 1 1 Institute of Neurology Gloriosa superba, a flowering plant widespread in South and Southeast Asia, is implicated in many cases of self- poisoning . It grows in the tropical climates of Africa, in Asian coun- tries, including India, Sri Lanka, Malaysia, and Burma, and in Australia and Pacific islands. It is often cultivated in tropical, and South Africa, Madagascar, Indonesia, Malaysia, and Myanmar. The electrocardiogram showed further T elevation (Figure2). Gloriosa superba is a perennial, usually climbing, plant producing sparsely-branched, annual stems from an underground tuber. The presumed mechanism is a transient episode of SIADH. Gloriosa superba is an ornamental herb, wildly found in the tropics especially in the southern parts of India and Sri Lanka. Key Words : Poisoning, Glory Lily, Gloriosa superba intense vomiting, severe bloody diarrhea, delirium, loss of consciousness, convulsions followed by multi-organ failure with respiratory distress, coagulopathy, renal failure and progressive polyneuropathy within 12 - 36 hrs. Niyangala (Gloriosa Superba) Poisoning Complicated with SIADH 114 also been associated with hyponatremia. Gloriosa superba (GSb) is a highly poisonous plant and its toxicity is due to anti-mitotic effects of constituents such as colchicine and gloriosine on rapidly proliferating cells. Author Hem Chunder Bhuttacharjee 1 Affiliation 1 Sub-Assistant Surgeon, Baraitch. The flowers are pollinated by Sugar Birds, Butterflies. Refractory hyponatremia in a euvolaemic patient few days after Niyangala poisoning is very unusual. Akhila CBG, (MSc RT) Postgraduate in Respirat ory Therapy, School of Allied Health . These herbal medicines are gaining popularity throughout the world as they are considered to be safe and effective. By the fifth day he developed bleeding gums and subconjunctival haemorrhages and haematuria. An 18-year-old woman, with a 2-year history of FMF treated with colchicine, took 9 colchicine pills (4.5 mg) to relieve severe abdominal pain. “Colchicine Poisoning: The Dark Side of an Ancient Drug.” Clinical Toxicology 48.5 (2010): 407-414. A hospital-based study in western Sri Lanka showed that out of 4556 cases of poisoning, 2.5 % were caused by plants and mushrooms, and Gloriosa superba was the commonest plant poison, being responsible for 44 % of them . J., 1: 1023-1024. Gloriosa superba L. (family Colchicaceae) is not only a notorious human and livestock poison, but is also widely used in several indigenous systems of medicine for the treatment of various human ailments. Gloriosa superba is a slender, herbaceous vine grown from a thick tuberous rootstock. Case of Poisoning by Gloriosa Superba Ind Med Gaz. We present a case with typical features of G superba toxicity. G. superba has caused illnesses and even fatalities to humans and animals due to both intentional and accidental poisoning. CASE REPORT A 28-year-old woman, previously healthy, presented with abdominal pain, diarrhoea and profuse vomiting. Diagnosis and Treatment of Colchicine Poisoning. Gooneratne BWM (1966) Massive generalized alopecia after poisoning by G. superba. Gloriosa Superba Poisoning in Sri Lanka R.M.M.K. Williams & Wilkins, Baltimore. They should be planted on a trellis for support but stems can be damaged if handled too much to train them. Colchicine is the alkaloid extract of Gloriosa superba and it is used in many rheumatological and immunological diseases. Acute intoxication following the ingestion of G. superba results in gastrointestinal and haematological abnormalities, hepatic and renal insufficiency, cardiotoxicity and hair loss. Scientific Classification. On admission, she was stable; we gave activated charcoal and treated Figure 1 Gloriosa superba—flower. Br. Gloriosa superba 'Rothschildiana' glory lily 'Rothschildiana' was £4.99 Buy from £2.99 at the RHS Plants Shop. It belongs to plant family Liliaceae. Gloriosa superba is distributed throughout tropical India, and in Andaman islands. All parts of the plants are toxic, especially the tuberous rhizomes in view of their high content of colchicines and its derivatives. Colchicine is also present in other members of the Colchicaceae family. It is hardy to zone (UK) 9. A hospital-based study in western Sri Lanka showed that out of 4556 cases of poisoning, 2.5 % were caused by plants and mushrooms, and Gloriosa superba was the commonest plant poison, being responsible for 44 % of them . Keywords. The chemical in the superb lily (Gloriosa superba) that causes it to be toxic is colchicine. Gloriosa superba (GSb) is a highly poisonous plant and its toxicity is due to anti-mitotic effects of constituents such as colchicine and gloriosine on rapidly proliferating cells. Credit: Brian Gratwicke. Suitable for: light (sandy), medium (loamy) and heavy (clay) soils and prefers well-drained soil. Vidanalage, Chaminda J. Kande, Rohan Ekanayeka, and Deepthi K. Wijewardane. Notes on Toxic plant chemicals: Two alkaloids, colchicine and gloriosine, are found in the tubers of glory lily. Though poisoning with Gloriosa superba is rare it is fatal and requires aggressive and prompt treatment is mandatory from saving the patient from death. Ind J Resp Care 2013; 2:336-8. Common names include flame lily , climbing lily , creeping lily , glory lily , [1] gloriosa lily , tiger claw , [2] and fire lily . was £4.99 Buy from £2.99 at the RHS Plants Shop. Poisoning is known to cause very rapid and severe clinical manifestations due gastro intestinal, neurological, cardiac and bone marrow toxicity. “Case Report: A Rare Case of Attempted Homicide with Gloriosa Superba Seeds.” BMC … Background. Poisoning is known to cause very rapid and severe clinical manifestations due gastro intestinal, neurological, cardiac and bone marrow toxicity. We report the case of an elderly woman who consumed the tubers of Gloriosa superba as treatment for her joint pains and died of its toxicity. Accidental or suicidal poisoning by Gloriosa tubers is well known in Sri Lanka. Colchicine is concentrated in the seeds and tubers and this mediates its toxicity. Get involved. Gloriosa superba , a flowering plant widespread in South and Southeast Asia, is implicated in many cases of self-poisoning. Gloriosa superba is a deciduous Perennial Climber growing to 2.5 m (8ft) by 0.3 m (1ft in) at a medium rate. Gloriosa superba and its conservation through micropropagation Nikhila, G. S., Sangeetha, G. and *T. S. Swapna Department of Botany, University College, Thiruvananthapuram-34, Kerala, India. Accidental or suicidal poisoning by Gloriosa tubers is well known in Sri Lanka. Figure 2: A patient with C-PAP ventilation at ICU on day 3 of Gloriosa superba poisoning 4. Anagen effluvium, the shedding of anagen hair, leads to diffuse non-scarring alopecia. We describe a 28-year-old woman who developed delayed encephalopathy after eating G superba tubers. Gloriosa superba (GSb) is a highly poisonous plant and its toxicity is due to anti-mitotic effects of constituents such as colchicine and gloriosine on rapidly proliferating cells. Massive generalized alopecia after poisoning by Gloriosa superba. Gloriosa superba poisoning - A case report. GLORIOSA SUPERBA International Programme on ... Ordog G and Wasserberger J (1996) Ellenhorn's Medical toxicology: diagnosis & treatment of human poisoning, 2nd ed. (2) Hyponatremia in the initial phase can be easily corrected with fluid replacement with isotonic saline. Received 10 July, 2014; Accepted 11 November, 2014 Gloriosa superba L. (Liliaceae) is an important medicinal herb of Asia and Africa. Key words: Gloriosa superba, multiorgan dysfunction, bleeding manifestations, fresh frozen plasma, death. Tubers of this plant contain several alkaloids. The aims of this study were to make standardized herbal preparations by determining the effects of decreasing of uric acid level and conducting toxicity test. Wed Jun 21, 2006. Case of Poisoning by Gloriosa Superba. The leaves alternate or appear opposite and are, simple, strap-like with a tendril-like tip. Colchicine poisoning can occur after ingestion of tubers of Gloriosa superba [14] often when they are mistaken for yams (Ipomoea batatas), which they resemble [15]. The toxicity limits its practicality for humans as well as canines at higher doses, however. Namal Rathnayaka*1,2, P.E.A.Nishanthi Ranathunga3, Ravindra Fernando4 1 ... Three died while having treatments in ICU. By Kerry A. Schwarz, PharmD, CSPI. Traditional practitioners in rural areas use plant parts or extracts to treat various ailments. Gloriosa superba is a species of flowering plant in the family Colchicaceae. Here, we report a case of massive alopecia caused by Gloriosa superba poisoning. In adults the main symptoms are gastrointestinal, and children have more severe symptoms, including sweating, hypotension, jaundice, bradycardia, and convulsions [16]. treated with analgesics and frusemide. Colchicine is used in the treatment of gout and rheumatism. The stems are usually up to 3 metres long, though occasionally to 6 metres; they can be erect, or they can climb into surrounding vegetation where they attach themselves by means of tendrils at the ends of the leaves 701. We aim to enrich everyone’s life through plants, and make the UK a greener and more beautiful place. tions of Gloriosa poisoning. Colchicine is a widely prescribed and effective medication for the treatment of gouty arthritis. Gloriosa superba is a plant that grows wild in several parts of South India. Plants such as autumn crocus or meadow saffron (Colchicum autumnale) and glory lily (gloriosa superba) contain colchicine alkaloids. Hecontinued to complain of chest pain on the fourth day. Sciences, Manipal. Keywords: Niyagala; Gloriosa superba; plant poisoning; colchicine Corresponding Author: R M M K Namal Rathnayake, E-mail Received: June 2016, Accepted revised version July 2016, Published: August 2016 Competing Interests: Authors have declared that no competing interests exist Introduction Plant poisoning may be accidental or intentional. At this stage haematological investi-gationsshowedhaemoglobin9.5 g/dl,whitecellcount 2.8 x99/1, platelet count 20x 109/1, bleeding time … Six hours before, she had eaten G superba tubers when attempting to end her life after a domes-tic dispute. The Royal Horticultural Society is the UK’s leading gardening charity. Colchicine is derived from Colchicum autumnale and Gloriosa superba and is used to treat acute gout and familial Mediterranean fever (FMF). Keywords: Gloriosa superba seeds, Poisoning, Colchicine, Sri Lanka Background Gloriosa superba is a plant in the family Colchicaceae. Introduction. The flowers grow on long stalks and are 6-parted, yellow or red with wavy margins. Gloriosa superba (44%), and Ricinus communis (24%) were the commonest plants responsible for poisoning; 39% of the victims were less than 15 y old. Musculoskeletal adverse effects range from myopathy to rhabdomyolysis. This compound is often employed to treat Behçet's disease and gout in small doses for humans. Gloriosa superba. The plant is self-fertile. The botanical name of Flame lily is Gloriosa superba. Med. Br Med J, 1: 1023-1024. 1872 Jul 1;7(7):153. ; 7 ( 7 ):153 are pollinated by Sugar Birds, Butterflies several parts of the Colchicaceae.. Hecontinued to complain of chest pain on the fourth day in gastrointestinal and haematological abnormalities, hepatic and insufficiency... ’ s leading gardening charity, strap-like with a tendril-like tip gardening charity its toxicity a thick rootstock. Alopecia caused by Gloriosa superba ) contain colchicine alkaloids patient with C-PAP ventilation at on. And familial Mediterranean fever ( FMF ) days after niyangala poisoning is known to cause very rapid and clinical... Chemicals: Two alkaloids, colchicine, Sri Lanka Background Gloriosa superba a plant in the seeds tubers. 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